Discontinue interfering medicines for at least 5 fifty percent-life in advance of administration of either the dosimetry or an iobenguane dose. Don't administer these medicines until finally at the very least seven times following Just about every iobenguane dose.
Not known; not sympathomimetic; could improve dopamine ranges from the Mind by binding into the dopamine transporter and inhibiting dopamine reuptake
Prevent coadministration of sensitive CYP3A4 substrates with ivosidenib or exchange with substitute therapies. If coadministration is unavoidable, check clients for loss of therapeutic result of those drugs.
Belzutifan is usually a CYP2C19 substrate. Coadministration with CYP2C19 inhibitors may perhaps boost incidence or severity of adverse effects. Keep track of for anemia and hypoxia and reduce belzutifan dose as proposed.
FYCOMPA is usually a prescription medication applied on your own or with other medicines to take care of partial-onset seizures with or with no secondarily generalized seizures in individuals with epilepsy aged four and older and with other medicines to deal with Key generalized tonic-clonic seizures in people with epilepsy aged twelve and more mature. Vital SAFETY Information and facts
Indicated to further improve wakefulness in Grownups with too much sleepiness connected to shift get the job done disorder (SWD)
eslicarbazepine acetate will boost the level or effect of modafinil by impacting hepatic enzyme CYP2C19 metabolism. Use Caution/Monitor.
Sufferers need to be encouraged to talk to their healthcare company quickly whenever they working experience a rash or any allergic reaction, melancholy, anxiety, or indications of psychosis or mania.
Lots of people choose medication but nonetheless have seizures. When this transpires, These are referred to as "breakthrough seizures".
A 400 mg dose of modafinil is useful for bigger individuals or Individuals who have developed a tolerance to modafinil with prolonged-phrase use.
[242] The medical trials which have tested modafinil for a remedy for stimulant here abuse have didn't reveal its efficacy and also the optimum dose and length of modafinil cure remain unclear, and modafinil isn't a advised treatment method for stimulant abuse.[242] Schizophrenia[edit]
Allergic reactions for example rash, angioedema, anaphylaxis, and Stevens–Johnson syndrome can be activated by an immunological reaction to modafinil or its metabolites.
Blood levels of cyclosporine could possibly be lessened when made use of with PROVIGIL. Checking of circulating cyclosporine concentrations and proper dosage adjustment for cyclosporine really should be deemed when employed concomitantly with PROVIGIL.
fosphenytoin will lessen the extent or result of modafinil by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor.